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Although the mechanism(s) underlying NASH progression remain to be fully elucidated, accumulating evidence suggests that both oxidative stress and the pro-inflammatory cytokine tumor necrosis factor- (TNF) are critical contributors in this process 5

Upon oxidative stress or electrophilic challenge, Nrf2 dissociates from Keap1, accumulates, translocates to the nucleus, and binds ARE sequences, initiating transcription of protective genes including HO-1, NQO1, and GSTs, substantially amplifying the cells antioxidant capacity (Jayakumar et al

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doi: 10.1007/BF00296636 83 RousseauKLe BelleNPichavantKMarchelidonJChowBKCBoeufGet al