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Since the gut is a gateway for environmental pathogens to enter, and the CNS and ENS participate in pathogen resistance mechanisms, the microbial flora and their metabolites are essential for promoting tight-junction expression and maintaining bloodbrain barrier (BBB) function ( Drosophila model of AD (Wu et al., 2017)

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Supports Fat Metabolism The liver has to break down fats efficiently

doi:10.1007/s12178-025-09990-7 Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JHS

That slowdown signals metabolic adaptation, and that is when a second agent with a different mechanism provides the most benefit

doi: 10.1016/j.diabres.2018.08.010