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It has been found that mutations in the amyloid protein precursor ( APP ), presenilin-1 ( PSEN1 ), and presenilin-2 ( PSEN2 ) genes are associated with autosomal dominant early-onset familial AD, while apolipoprotein E4 ( APOE4 ) represents the most significant genetic risk factor for late-onset sporadic AD, contributing to the deposition of A peptides and hyperphosphorylated tau proteins (Giau et al., 2019

All the samples were scanned in the range of 4000400 cm 1 35

3.5 Rheumatoid arthritis Immune dysfunction and tissue inflammation are important features of RA (203, 204)

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doi: 10.1182/hem.V22.5.202554 307 AstleJMHuangH

Aging Cell 16(1):104112