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Do not shake vials vigorously

These epidrugs are typically small-molecule DNMT inhibitors that directly affect catalytic sites, whose mechanism of action is unrelated to DNA incorporation

[PubMed: 1411543] 98

At the molecular level, the mechanism has been structurally resolved by NMR spectroscopy (Nature Communications, 2025): FOXO4-DRI binds to the disordered p53 TAD2 domain and forms a transiently folded complex through both the FOXO4-derived peptide region and its cationic cell permeability element