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Orphanet J Rare Dis 2 , 16 (2007)

Di Cesare Mannelli, L., Zanardelli, M., Failli, P

Both the thioredoxin reductase/thioredoxin and glutathione reductase/glutathione/glutaredoxin pathways (ascorbate-glutathione cycle in plants) 45 use electrons from NADPH to reduce cellular disulfide bonds and certain reactive oxygen and reactive nitrogen species

Clustered Image Maps (CIM) and relevance networks were constructed to visualize the results of the analysis

ROS accumulation triggers OS, cellular damage, mitochondrial dysfunction, A deposition, Tau hyperphosphorylation, synaptic loss, and neuronal deathkey factors in AD progression (Aliev et al., 2004

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