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10.1038/325529a0 41 KaindlA

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Glutathione as a reducing agent in cytoplasm is important in imparting antioxidative properties to the bacteria

To determine how APR-246 depletes GSH, we applied mass spectrometry to show that 2-methylenequinuclidin-3-one (MQ), the active component of APR-246, reacts with GSH inside cancer cells (Fig