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Taken together, these findings support the involvement of the gut microbiota and related metabolic pathways in FM pathophysiology and provide a rationale for exploring personalised dietary approaches, such as moderate caffeine intake, increasing omega-3 intake, adopting a low glycaemic index diet, and reducing the foods high in oxalate [40]

GDF8 is cleaved by the four members of the TLD family, preferentially by TLL2, whereas GDF11 is cleaved by BMP1 and TLL1

Following this, the receptors were then embedded in a rectangular 126 x 126 1-palmitoyl-2-oleyl-sn-glycerol-3-phosphocholine (POPC) bilayer (previously built by using the VMD Membrane Builder plugin 1.1 at considering the coordinates retrieved from the OPM database to gain the correct orientation within the membrane, while removing the lipid molecules overlapping the receptor TMD bundle

10.1016/s0893-133x(01)00229-9 46 HsiehJ

Absence of a strong signal is not the same as a well-characterised safety profile