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44 There are ongoing studies evaluating the efficacy of orforglipron on weight loss and cardiovascular outcomes (clinical trial number NCT05803421

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As for the secondary outcome measures of gastrocnemius muscle mass and flexion foot contracture, there was a significant decrease in muscle mass seen in the right hind limb that underwent sciatic nerve transection, in comparison to the left hind limb that was not operated on

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But, before you write them off as a bad friend or a negative person, it might be helpful to try and better understand where they are coming from