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The enzyme catalyzes the methylation of nicotinamide (a form of vitamin B3) using S-adenosyl-L-methionine (SAM) as a cofactor, producing 1-methylnicotinamide (1-MNA) as a metabolic byproduct

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Once your levels stabilize, you may only have to get injections less often to keep your levels reasonable

Managing common side effects Like other weight loss medications, tirzepatide can also cause mild to moderate gastrointestinal side effects such as nausea (most common), diarrhea, and constipation, especially during the start of treatment or when the dose is increased

Secondly, the freed-up vitamin B12 must combine with another protein (called the intrinsic factor) in the stomach so that the body can absorb it

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