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Gian Carlo Rastelli (19331970), whose work led to cardiac surgery useful for children with trisomy 21

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Consistent with the results from germline XKR8 KO mice challenged with LPS, neutrophil-specific XKR8 KO mice displayed significantly reduced NET formation in the lungs, lower levels of extracellular dsDNA in BALF and mitigated lung injury, despite similar levels of neutrophil infiltration following LPS challenge (Fig

Histological samples were obtained from lung tissue of four infected mice for each strain and timepoint

Exactly 100 L mineral oil per well (preheat to 30 C) was added to reduce interference from ambient oxygen

The process is quick, requiring no extended monitoring afterward