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Additionally, siRNA contributed to downregulating Nrf2 protein expression

[42] for highest BaP concentrations in lamb steak (5.8 mg/kg) followed by chicken drumstick (4.0 mg/kg)

It seems to enhance the effects of those treatments

doi: 10.1006/bbrc.1999.1884 75 LettsJASazanovLA

Interestingly, GPx3 was identified as the sole protein with the most significant reduction in signal for children affected with konzo, a finding that was further validated using ELISA as a secondary method of confirmation