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People with Lebers hereditary optic neuropathy, a rare inherited optic nerve disorder, may be at risk of severe optic nerve damage with cyanocobalamin

Vitamin B 12 and nucleic acid metabolism The figure shows pathways of folate and vitamin B 12 metabolism of nucleic acid synthesis and methylation reactions

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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Safran MR, Graham SM

B12 deficiency can result from dietary factors such as a lack of animal products or from conditions affecting absorption like pernicious anaemia or gastrointestinal surgery