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While some positive outcomes have been observed in cell and animal studies, substantial barriers remain before these results can be implemented in clinical settings

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The presence of anti-inflammatory cytokines such as IL-10, IL-4, or IL-13 induces the appearance of neuroprotective reactive astrocytes, which in turn have the capacity to release IL-4, IL-10, and TGF- (Oksanen et al., 2019)

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