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[PubMed] [Google Scholar][20] Chen HC, Wiek J, Gupta A, Luckie A, Kohner EM

BPC-157 ,

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Unlike growth factors, which act via receptor-specific pathways, BPC-157 and TB-500 function through intracellular signaling modulation and cytoskeletal regulation

This mechanistic complementarity means combining the peptides addresses more healing pathway simultaneously than either alone

(Papp) : Papp = dQ/dt x 1/A C 0 The apparent transmission coefficient (Papp) of all polypeptides was calculated using the following equation: Papp = dQ/ 0 dQ/dt dt Caco-2 , C 0 0 , A .If dQ/dt is the amount of solute transported across the Caco-2 barrier at time dt, C 0 is the solute concentration in the apical compartment at 25 mg/mL, Caco-2 :3 (P app = 10.3).Sodium kenodeoxycholate had the highest permeability of the SEQ ID NO: 3 peptide across the Caco-2 cell layer at 25 mg/mL (P app = 10.3)