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In a recent randomized clinical trial investigating the IL-17A inhibitor secukinumab, lesional skin transcriptomic profiles showed Glutathione-S-transferase 3 among the top 10 upregulated genes after 12 weeks of treatment (111)

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While sedated under ether anesthesia, deep partial skin thickness burns were induced on the back of each test subject through the method of control burning

Kumar et al., 2011)

[PubMed: 4753432] 64

If you wish to incorporate multiple Vitamin Cs, Retinoids, and/or Direct Acids into your skin care regimen, we suggest using them on alternate evenings and waiting until your skin has adjusted to one before introducing another