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USA 107 , 20372042 (2010)

Revisiting the oxidation of flavonoids: loss, conservation or enhancement of their antioxidant properties

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Molecular modeling indicates that the substitution of a valine to glutamic acid at residue 411 reduces the binding affinity of linolenic acid, a reported exogenous ligand for the NHR-49 ortholog, HNF4, as well as other potential fatty acid binding partners with comparable structure (Supplementary Fig