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9 1 Administer SUBLOCADE maintenance doses monthly with at least 26 days between doses 1 Strongly consider prescribing naloxone along with SUBLOCADE because patients being treated for OUD are at risk of overdose 1 Real-world, post-marketing data indicate that HCPs prescribed some patients the SUBLOCADE 300mg maintenance dose 9 Nearly half (47.8%) of patients were prescribed at least one 300mg maintenance dose following 2 initial doses of 300 mg 9 In the Phase 3 double-blind, placebo-controlled study, there was no difference in efficacy between the 300mg and 100mg doses 1,3 Post-marketing data were analyzed for 21,224 US patients who were prescribed at least 4 SUBLOCADE injections from April 1, 2023 to September 30, 2024

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The extensive use of chemoprophylaxis would likely reduce by 300,000 the total number of cases in the United States in the next 15 years