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P.et al (2018)

Retatrutide is the only late-stage compound that provides significant glucagon receptor activation alongside GLP-1 and GIP agonism

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Expression and purification of RAMP ECD-CTR ECD fusion proteins The general expression procedure of the calcitonin receptor (CTR) extracellular domain (ECD) alone and RAMP1, -2, or -3 ECD fused with CTR ECD as functional amylin receptor ECDs was previously reported [21,23]