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Therapeutic strategies targeting SQOR must therefore be calibrated to the disease context

Promoting angiogenesis: It may activate pathways like VEGFR2-Akt-eNOS, encouraging new blood vessel formation (angiogenesis) to repair damaged tissues

[DOI] [PubMed] [Google Scholar] 155.Qiang R., Li Y., Dai X., Lv W

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As such, it is apparent that additional experimentation focusing on genomics, environmental/nutritional components and their crosstalk is warranted to determine the causal factor(s) that reduce both cystine and selenoprotein levels in children affected with konzo to unravel the biological mechanism behind this disease