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Hepatology 76:1831 Bjrnsson H, Bjrnsson E (2022) Drug-induced liver injury: pathogenesis, epidemiology, clinical features, and practical management

186 Most importantly, DNA damage-induced activation of ataxia-telangiectasia mutated- and Rad3-related protein (ATR) promotes Ser132 and Ser368 phosphorylation of USP20, enhancing its stability and conferring oxaliplatin- and ferroptosis-resistance in HCC cells

Biochem Biophys Res Commun 373(2):246252 You M et al (2015) Sirtuin 1 signaling and alcoholic fatty liver disease

10.1038/s41419-019-1386-7 50 LecumberriE.DupertuisY

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The rectal administration is also beneficial for patients who may have difficulty swallowing pills or for those who have gastrointestinal issues that could interfere with the absorption of oral medications