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For example, severe neuroinflammation (brain fog) can dysregulate the autonomic nervous system, leading to worsened POTS symptoms (tachycardia), which in turn triggers mast cell degranulation (histamine release)

El-Dakroury WA, Zewail MB, Asaad GF, Abdallah HMI, Shabana ME, Said AR, Doghish AS, Azab HA, Amer DH, Hassan AE, Sayed AS, Samra GM, Sallam A-AM

Briefly, urine samples were acidified to pH 3 and centrifuged at 1500 g for 10 min at 4 C

Synthesis declines 1%/year after age 20[2]

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To orient the reader, Figure 2 schematizes the core oxidative-stress network, with compound-level cross-references in Appendix B: Supplementary Table 1