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[DOI] [PubMed] [Google Scholar] Kris-Etherton PM, Taylor DS, Yu-Poth S, Huth P, Moriarty K, Fishell V, Hargrove RL, Zhao G, Etherton TD

After several months trying to develop a robust cytotoxicity cell-based assay, we always observed high variability on the upper asymptote of the dose-response curve

Acta Histochem 118:3137 Dilshara MG, Jayasooriya RG, Park SR, Choi YH, Choi IW, Kim GY (2016) Caffeic acid phenethyl ester enhances TRAIL-mediated apoptosis via CHOP-induced death receptor 5 upregulation in hepatocarcinoma Hep3B cells

We show that zonulin is a central factor in this process as it disrupts intestinal TJ proteins, enhances intestinal permeability and leads to Th1 and Th17 infiltration in the lamina propria before the onset of murine and human arthritis

Immune checkpoint molecules like PD-1 (programmed death-1) and CTLA-4 (Cytotoxic T lymphocyte-associated antigen-4) function as negative regulators of immune activation, and when triggered by tumor or tumor-associated cells, they suppress immune responses (105, 125128)

Arginine deiminase (ADI) ADI is an enzyme that catalyzes the interconversion of arginine and citrulline