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1 Introduction Drug metabolism is the process by which the body processes pharmaceuticals from initial absorption to distribution to action to their final removal ( Drug Metabolism occurs in two phases in the liver: phase I and phase II ( The CYP450 family is widely diverse, with multiple isoforms such as CYP3A4, CYP2D6, CYP2C9, and CYP1A2, which promote the biotransformation of a broad range of xenobiotics and endogenous compounds ( Recently, the concept of the exposome has appeared as a potential framework for interpreting how the environment shapes health and diseases throughout life