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Under stress and/or catabolic conditions such as cancer, sepsis/infections, post-surgery and trauma, the endogenous synthesis of glutamine does not appear to meet the human body demand, and hence glutamine assumes the role of a conditionally essential amino acid (Reference Liu, Ma and Luo6Reference Altman, Stine and Dang8)

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Although these strategies laid theoretical foundations, they were hampered by limited mechanistic understanding, inconsistent efficacy, and frequent adverse events

Four serious adverse events were observed in the ARA 290 treatment arm

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