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For instance, in Zambia, although the Medicines and Allied Substances Act of 2013 mandates the Zambia Medicines Regulations Authority to regulate and control the sales of herbal medicines, there is neither a system of registration nor a post-marketing surveillance system for herbal medicines (World Health Organization, 2005

Systemic comorbid medical conditions share pathways involving peripheral IRS and O&NS pathways, e.g., chronic obstructive pulmonary disease, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, irritable bowel syndrome, psoriasis, type 1 and type 2 diabetes, HIV infection, obesity, and chronic fatigue syndrome [1]

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But the early trajectory is compelling

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J Vis Exp (2016) 113:54228