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The proposed mechanisms include upregulation of beta-3 adrenergic receptors in adipose tissue, activation of the cAMP-PKA lipolytic cascade through enhanced catecholamine sensitivity, direct or indirect inhibition of acetyl-CoA carboxylase (ACC) reducing de novo lipogenesis by approximately 43-57% in vitro, and activation of hormone-sensitive lipase (HSL) with increased glycerol release

Compared with domperidone alone, acupuncture add domperidone treatment decreased the scores of all cardinal symptoms of the Gastroparesis Cardinal Symptom Index (GCSI), increased scores of the Satisfaction with Life Scale (SWLS) and the social functioning domain of the Short-Form (SF-36) [93], indicating that acupuncture combined with medicine may be more effective than medicine alone

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