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Eur J Heart Fail 15(7):756762 McMurray JJ et al (2009) Design of the Reduction of Events with Darbepoetin alfa in Heart Failure (RED-HF): a Phase III, anaemia correction, morbidity-mortality trial

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This activation reduces HO levels, increases CAT activity, and upregulates transcription of antioxidant genes, including HO-1, which help maintain redox homeostasis 17