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Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response

The deletion of Lats2 or Mst1 may trigger the accumulation of cholesterol by increasing sterol regulatory element binding protein (SREBP) activity

IV therapy has long been used in a hospital setting, giving patients essential vitamins, minerals, and other nutrients to help them recover from illness or surgery

10.1038/s41418-017-0053-8 Cell Death Differ

10.1097/00001665-199409000-00003 202 MarreroJ.RodrguezA