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One factor that may contribute to this is that the rectum contains a thin membrane (the lamina propria) that harbors an abundance of HIV target cellsand only one layer of tissue separates these target cells from the rectal lumen

D., Dijkstra, G., Weersma, R

Initiation of cell cycle arrest can have contradictory effects on cells depending on context, resulting in either protection or senescence/apoptosis

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In a placebo-controlled pilot study, 30 patients received 1 million IU/day subcutaneous IL-2 every other day for 2 weeks, which was followed by a 2-week break, and this 4-week period was repeated twice ( post hoc per-protocol analysis which excluded patients from two sites, where the SRI-4 response rate was 100% in the placebo group showed a statistically significant difference in connection with the primary endpoint, which encourages further investigations (86)

Massa NML, Silva AS, Toscano LT, Silva JD, Gomes R, Persuhn DC