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For example, only high doses (50 mg/kg in UUO mice) of kaempferitrin can achieve therapeutic effects (Qin et al., 2022), its specific targets in iron metabolism (e.g., hepcidin or transferrin receptor regulation) remain uncharacterized

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Cell Mol Life Sci 79(7):387 Meng X et al (2021) ADAMTS-13-regulated nuclear factor E2-related factor 2 signaling inhibits ferroptosis to ameliorate cisplatin-induced acute kidney injuy