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Some affected metabolites link to amino acid metabolism and changes in key pathways such as amino acid metabolism has been observed (184, 187, 408, 409)

Specifically, we used genetic variants to predict l-carnitine, and obtained their associations with coronary artery disease (CAD), ischemic stroke, heart failure, and atrial fibrillation, as well as CVD risk factors (type 2 diabetes, glucose, HbA1c, insulin, lipid profile, blood pressure and body mass index) in large consortia and established cohorts, as well as sex-specific association in the UK Biobank

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Furthermore in both diseases there are elevated liver enzymes like alanine transaminase (ALT) and aspartate transaminase (AST)an indicator of liver injury [55]

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However, maintaining consistent levels in the body may support long-term effectiveness