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Using biotin-probe profiling, gene knockout/knock-in models, UPLC-MS metabolomics and computational simulations, the researchers demonstrated that: CD36 binds multiple PROTAC molecules (including SIM1-Me, MZ1 and ARV-110) as well as large-molecule drugs such as rapamycin, navitoclax, birinapant, tubacin and doxorubicin, thereby promoting their cellular uptake and pharmacological activity

Deandrea S, Talami R, Foschi R, Montella M, Dal Maso L, Falcini F, et al

Mushrooms treated with 0.5 mg/L of ozone for 30 and 60 min showed firmness increases from 15.3 to 16.4 N and 18.1 N after 4 days, followed by declines to 5.9 N and 14.3 N after 14 days

Another essential component for executing ferroptosis is acyl-CoA synthetase long-chain family member 4 (ACSL4), as it influences the necessary lipid composition in ferroptosis [46]

These findings illustrate that oxysterols, particularly 25-OH, 7OH, and 7KC, can trigger oxidative stress, apoptosis, and inflammation in RPE cells, thereby inducing retinal degeneration

Mitochondrial dynamics and metabolic regulation