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The 2004 Bissett study in International Journal of Cosmetic Science used twice-daily 5 percent niacinamide for 12 weeks in 50 women aged 40 to 60, documenting significant reductions in fine lines, hyperpigmentation spots, blotchiness, and yellowing [13]

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In the case of the cationic liposomes, the increase in SA concentration caused only a slight decrease in the value of the zeta potential from 48.8 1.9 mV to 42.3 1.8 mV for 7 and 15% SA, respectively