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TREM2 lipid sensing sustains the microglial response in an Alzheimers disease model

When Hedgehog binds to PTCH, activated Smo transmits signals through Gli, Sufu, and Kif7, resulting in the generation of the Gli-activated form (GliA), which translocates to the nucleus and leads to transcriptional activation of Hh target genes

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DOI: 10.1007/s00018-003-3206-5 51

Because of the high Hb content within MPs, this may result in NO scavenging and pro-coagulant activity enhancement and could therefore significantly affect NO bioavailability