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The pathogenesis is unclear, but probably related to mitochondrial membrane function and ATP production

In acute leukemia, EZH2 utilizes a hidden transactivation domain in conjunction with cMyc and p300 to activate gene expression, contributing to tumorigenesis alongside its classical role in transcriptional repression [21]

Among the surveyed related articles, animal studies revealed that these bioactive components mainly modulate the gut microbiota by reversing the Firmicutes/Bacteroidetes ratio, increasing the relative abundance of beneficial bacteria, such as Bacteroides , Akkermansia , Lactobacillus , or decreasing the abundance of harmful bacteria, such as Lachnospiraceae , Desulfovibrio , Lachnoclostridium