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Decreased lean body mass and BMI correlate with higher perioperative morbidity, shorter progression-free and overall survival 38

Intracellular reactive oxygen species production may cause cellular damage ( Reference Streck, Vieira and Wannmacher 9 ) and disorders of the antioxidant defence system ( Reference Blundell, Jones and Rose 12 ) , demonstrating a mechanistic connection between hyperhomocysteinaemia, oxidative stress and disease

Furthermore, the CSF-1/CSF-1R signaling pathway, as a key regulator of macrophage survival, proliferation, and differentiation, represents another critical intervention target

Bartralot R, Garca-Patos V, Sitjas D, et al

The published research literature includes a body of safety-relevant findings in cell-culture and animal-model contexts