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In addition, the upregulation of SIRT7 expression significantly improves renal EMT and subsequent renal fibrosis in hypertensive mice and reverses the decreased KLF15 expression induced by Ang II

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In a randomized, placebo-controlled phase 1 clinical trial, 14-day treatment with TLC-2716 was well tolerated (primary endpoints) and resulted in placebo-adjusted reductions up to 38.5% in plasma TG and 61% in postprandial remnant cholesterol (secondary endpoints)

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The peptide appeared to counteract L-NAME-induced hypertension while also reversing L-arginine-induced hypotension [8]

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Given what we do understand about the potential action on cellular signaling pathways this could pose serious risk

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