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Cu chelators A number of Cu-chelating agents such as TTM, trientine, and d-penicillamine have been developed and tested for their anti-tumor activity in both animal models as well as in clinical trials

Bailey AP, Koster G, Guillermier C, Hirst EM, MacRae JI, Lechene CP, Postle AD, Gould AP (2015) Antioxidant role for lipid droplets in a stem cell niche of drosophila

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Zarjou A, Jeney V, Arosio P, Poli M, Zavaczki E, Balla G, Balla J

In immunologically'cold'pancreatic and glioma tumor models, the combination of ZnCDA with RT resulted in a marked amplification of the anti-tumor effects

Conversely, iron-chelated lactoferrin inhibits osteoclast-mediated bone resorption by reducing the RANKL/OPG ratio, thereby increasing the bone mineral density (92, 94)