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Gastrointestinal adverse events, primarily nausea, vomiting, diarrhea, and constipation, are the predominant side effects, occurring most frequently during dose escalation and generally diminishing with continued treatment

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There's a big gap in this department

The trial aims to recruit 7,000 overweight or obese participants, including those with and without type 2 diabetes

Theoretical concerns about angiogenesis apply here as well