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When the gradient of blue was obvious in the first 3 to 4 holes of the standard hole, the gradient of the last 3 to 4 holes was not obvious, and the process could be terminated

71 Therapeutic modulation of the autophagy-mitophagy axis in metabolic diseases Pharmacological interventions Several pharmacological agents already in clinical use exert metabolic benefits, at least in part, through activation of autophagy and mitophagy

Hyperglycemia is a major and common feature of type 1 and type 2 diabetes, with high concentrations of glucose directly and negatively affecting brain function via AGEs and reactive oxygen species (ROS) and promoting abnormal DNA modification 34

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Nitric oxide also plays a role in iron trafficking because it mimics the consequences of iron starvation and triggers iron uptake by cells