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Huangjia Ruangan Granule (HJRG) is a compound preparation of TCM known for its anti-liver fibrosis properties ( P

p53 Recent studies suggest that p53 plays an important role in controlling metabolism and ferroptosis and that p53 in normal cells can negatively regulate lipid synthesis and glycolysis and positively regulates oxidative phosphorylation and lipid catabolism

Although pharmacological efficacy of some drugs was claimed to be improved after administration of developed derivatives compared to parent drug dosing, in these studies, the derivatives as such were either shown to be active or their activity has not been investigated

This vulnerability is further complicated by the blood-brain barrier (BBB), which tightly regulates iron influx and efflux, creating distinct compartmentalization of iron metabolism [10]

It does not have to be converted but also has a shorter shelf life and may be pricier than others

With the correct vitamin B12 dosage, the daily requirement can be covered and the body stores sufficiently topped up