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Thus, the development of new treatment strategies to prevent RSV infections is a priority of the World Health Organization ( RSV Pathogenesis RSV transmission occurs via air, by contact with epithelium of the nostrils, mouth, or eyes of RSV-infected individuals, or by contact with a surface contaminated with the virus ( Once RSV enters the nostrils or mouth, it begins to infect airway epithelial cells (AECs) of the upper respiratory system ( in vitro cultures ( An in vitro AEC model was used to show that RSV infection is concentrated in groups of non-continuous cells or small groups of ciliated apical cells located in the epithelium of large airways ( in vivo ( in vivo , which exposes nociceptive nerve fibers and produces a cough reflex ( Well-differentiated primary pediatric bronchial epithelial cells (WD-PBEC) provide a suitable in vitro model to study RSV infection ( in vitro model imitates the physiological, functional, and morphological environment of the respiratory tract ( RSV does not cause the massive airway epithelium destruction observed in post-mortem lung samples from RSV-infected patients in the WD-PBEC in vitro model ( in vitro studies demonstrated that the cell monolayer remains intact, even when most of ciliated cells were infected with RSV

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10.1371/journal.pone.0085403 PLoS One 205 ZhaoC.LiW.DuanH.LiZ.JiaY.ZhangS.et al (2020)

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They are not FDA-approved drugs, but they are widely used in research and experimental settings to enhance understanding of healing mechanisms

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