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Further studies showed that sulindac binds to retinoid X receptor alpha (RXR) and induces autophagy in GABAergic neurons, leading to activation of the mitochondrial apoptotic pathway

This signaling enables the heart to adapt to energy demands and reduces fat toxicity in obesity models

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Professor Sikirics research contributions include: Initial isolation and characterization of BPC-157 from human gastric secretions Extensive investigations of gastroprotective and tissue healing mechanisms Pioneering studies on musculoskeletal tissue repair including tendon and muscle healing Research on cardiovascular protective effects and vascular injury healing Over 400 published papers examining BPC-157s pleiotropic effects across organ systems His work has established BPC-157 as one of the most comprehensively studied components in peptide-based regenerative research, though human clinical validation remains absent

Kersjes and his team audited Springer Nature publications to find any others that had used a version of the dataset, and they plan to retract a total of 38 papers, conference proceedings and book chapters, and remove all but 1 of these