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The primary outcome (effect size) was hypothesized to be the level of striatal CREB expression (upward stream regulator of BDNF) and attrition rate of 20%, setting the alpha level at 5% and power at 80% using a one-way ANOVA test within the four groups

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* Correspondence: Lidan Yang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers