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In line with this, John et al

Whether the impact of anesthesia followed by pain management has the same effects on the antioxidant system as abuse of opioids, amphetamines and other drugs affecting these systems is an issue that needs further research since such effects may be assumed to be a function of drug dosage, means of delivery, length of use and the degree to which tolerance develops

952 This combined treatment strategy could inhibit ferroptosis and inflammation after SCI, promote the recovery of nerve function in rats with SCI, and offer a new strategy for the construction of drug-synergistic cell therapy systems targeting ferroptosis