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TOX also increases IL-10.[ref][ref] IL-10 (interleukin 10): IL-10 is a regulatory cytokine that puts the brakes on the immune response, preventing excess tissue damage during inflammation

3.1 Antibacterial mechanisms mediated by conventional copper and copper alloys Copper and its alloys exhibit broad-spectrum antimicrobial activity through both contact-mediated killing and copper ion release, involving Cu 2+ and Cu + species (Vincent et al., 2018)

[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Xiao L., Wang J., Zheng J., Li X., Zhao F

Cardiac arrhythmias and pancreatitis have been reported

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Major obstacles include the lack of standardized quality control for botanical extracts, poor bioavailability, unclear pharmacokinetic profiles of bioactive compounds, and insufficient high-quality evidence from randomized controlled trials to confirm efficacy and safety