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165 In another study, a distinct senescence-like tetraspanin-8 (TSPAN8)+myofibroblastic CAF (myCAF) subgroup potentiates tumor stemness through SASP-associated factors IL-6 and IL-8, thereby promoting chemotherapy resistance in breast cancer

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Nevertheless, the high level of evidence showing a clear clinical benefit of this highly potent urate-lowering agent should help confirm the therapeutic principle of the treat-to-target ULT approach, already universally adopted by rheumatology guidelines

Briefly, patch motion correction and CTF estimation were performed and low-quality micrographs were discarded before an initial set of particles was picked via the blob picker and extracted

In view of robust patient blood management practices and despite stringent selection criteria, only ~ 56% of enrolled subjects were transfused (site range 1882%)

P., Poutanen, M., Duran-Torres, G., Garcia-Horsman, A., & Mannisto, P