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Examples of endogenous neurotrophic factors include BDNF, insulin-like growth factor-1, erythropoietin, granulocyte-colony stimulating factor, and hepatocyte growth factor, among others [269]

The Reality of Human Clinical Trials: Status and Safety Data Despite the immense commercial popularity, the multimillion-dollar grey market economy, and the incredibly robust body of preclinical animal data demonstrating miraculous healing properties, the landscape of rigorous, large-scale, placebo-controlled human clinical trials for these specific peptides remains extraordinarily sparse

As a result, chemical mediators (i.e., histamine, heparin, tryptase, cytokines) signal other immune cells to rush to the area

S.PapapanouM.MaheshwariA.VaidakisD

Cholia RP, Dhiman M, Kumar R, Mantha AK

& Franzini, R