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Furthermore, it can counteract the inflammatory actions of estrogen receptor (ER), contributing further to its immunoregulatory functions [164]

Collectively, these strategies demonstrate that metabolically targeting TAM subsets is a powerful approach to controlling ferroptosis, suggesting multiple avenues for combination therapies that integrate ferroptosis inducers, immune checkpoint modulators, and metabolic inhibitors

Res Sq BMP receptor 2 inhibition regulates mitochondrial bioenergetics to induce synergistic cell death with BCL-2 inhibitors in leukemia and NSLC cells

Moreover, given that drug exposure is expected to be highest in the olfactory bulbs compared to other brain regions, IN chelator therapy may be particularly beneficial for disorders involving early olfactory bulb pathology or localized iron dysregulation near the nasal region (Deng et al., 2024)

We observed that several lipid peroxidation-related markers were inhibited (Fig

S., Pensak, M