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2016 Nov;13:190200

However, vitamin B12 is unique amongst water-soluble vitaminswhilst it shares their aqueous properties, the body can store substantial amounts in the liver for several years

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Problem: severe nausea that does not improve Nausea that persists beyond 2 to 3 weeks at any dose level, or nausea severe enough to prevent eating for more than 24 hours, warrants medical attention